Translational Research and
Innovation strategy

Strategies from discovery to
treatment.

These are linked with the four research themes summarised below. Our endeavour is to demonstrate how we utilise novel advanced imaging with specific artificial intelligence tools (AI-ART doctoral training programme) and biomechanical-engineering to address mechanistic disease questions. To this end we will set up various platforms within our Centre with the already established precision medicine networks in Glasgow, Oxford and Cardiff (such as the National Consortium of Intelligent Medical Imaging (NCIM) and Radiomics in Oxford and Cardiff respectively) this would contribute to answering our biomechanistic questions with cutting edge tools. It is by utilising advanced spectroscopy, both light and electron microscopy quantitative imaging, as well as medical imaging that we can create a quantifiable spatio-temporal landscape related to underpinning the mechanisms in the dysregulation of molecular signalling.

See Research Case Studies

CTI Research
and Organisation

CTI’s areas of research are focussed on interdisciplinary translational research with a genuine impact on the quality of patient care. The overall research trajectory of CTI comprises of

Translational Cell Biophysics
Where the main objective is to investigate the structure-function of various proteins involved in multiple types of cancer signalling pathways particularly those controlled by lipid signalling events and immune environment. The interest is to investigate how these pathways are affected by the endomembrane morphology and cellular environment.
Advanced Bioimaging & Medical Devices
Here we aim to bring together physical scientists and engineers with healthcare professionals and life scientists in the development of leading- edge medical technology, medical devices and advanced imaging systems to address the questions related to the dysregulation of signalling pathways and mechano-sensory pathways. The scope of this theme spans from fundamental discovery through to clinical treatment and life-long care. Our vision is to foster creation of novel methods and devices that cover these pathways, creating a unique pipeline for therapeutic innovation.
Mechanisms of disease and regeneration: routes to new immune-biotherapeutics
Routes to new immune-biotherapeutics- our aim is to understand the molecular pathways responsible for physiological processes, how their dysregulation leads to disease and the manner they can be repaired or regenerated. The theme seeks to develop new therapeutics that include traditional small molecule chemical entities but better harness the new field of “biologic” medicines that span vaccines, monoclonal antibodies (and their variants) and cell-based therapeutics such as stem cells. We use interdisciplinary pharmacological, biochemical, chemical biology as well as cellular, molecular and genetic approaches to better understand, interrogate and manipulate these processes. Our approaches span in vitro/vivo models through to identification of biomarkers in groups of patients with a distinct disease phenotype or response to a therapeutic strategy.
Medicine Development
Provides international networking, collaboration and innovation in drug design and delivery with strong emphasis on the needs for patients. We have strong expertise in pioneering projects in drug design and delivery, facilitating partnership with pharmaceutical industry for medicines development and commercialisation. More specifically, it provides a robust consortium of specialised disciplines in, chemical biology, immuno-oncology, metastatic cancer and the microenvironment, skin cell biology and cancer, microbiology, photobiology. The medicines development includes biologics, antimicrobials, anti-ageing, anti-cancers and other therapeutic medicines with the potential for global impact across healthcare.

CTI Charter

In November 2020 we released the Charter for the Centre for Therapeutic Innovation. The Charter was implemented to allow members to have a clear understanding of what is expected from them in CTI, as well as what the benefits of being a member of the Centre are.

CTI charter

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